Toxic Granulation

Toxic granulations are darker-coloured granules that can be seen under a microscope in neutrophils, the most abundant class of white blood cells. These granules are often larger and more abundant than normal granules. Their presence is non-specific and usually signals a bacterial infection or inflammation. They can also be observed in late-pregnancy, when the bone marrow is recovering after chemotherapy or after treatment with drugs (Neupogen©, Neulasta©, Grastofil©) that stimulate the formation of granulocytes (neutrophils) by the bone marrow.